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Genetic, clinical and pharmacological determinants of out-of-hospital cardiac arrest:Rationale and outline of the AmsteRdam Resuscitation Studies (ARREST) registry

Authors :
Blom, M T
van Hoeijen, D A
Bardai, A
Berdowski, J
Souverein, P C
De Bruin, M L
Koster, R W
de Boer, A
Tan, H L
Sub Pharmacoepidemiology
Sub Gen. Pharmacoepi and Clinical Pharm
Dep Farmaceutische wetenschappen
Sub Pharmacotherapy, Theoretical
Pharmacoepidemiology
Pharmacoepidemiology and Clinical Pharmacology
Cardiology
Sub Pharmacoepidemiology
Sub Gen. Pharmacoepi and Clinical Pharm
Dep Farmaceutische wetenschappen
Sub Pharmacotherapy, Theoretical
Pharmacoepidemiology
Pharmacoepidemiology and Clinical Pharmacology
Amsterdam Cardiovascular Sciences
Amsterdam Public Health
Other departments
Source :
Blom, M T, Van Hoeijen, D A, Bardai, A, Berdowski, J, Souverein, P C, De Bruin, M L, Koster, R W, De Boer, A & Tan, H L 2014, ' Genetic, clinical and pharmacological determinants of out-of-hospital cardiac arrest : Rationale and outline of the AmsteRdam Resuscitation Studies (ARREST) registry ', Open Heart, vol. 1, no. 1, e000112 . https://doi.org/10.1136/openhrt-2014-000112, Open Heart, 1(1):e000112. BMJ Publishing Group, Open Heart, 1(1). BMJ Publishing Group, Europe PubMed Central, Open heart, 1(1). BMJ Publishing Group, Open Heart, ResearcherID
Publication Year :
2014

Abstract

Introduction: Out-of-hospital cardiac arrest (OHCA) is a major public health problem. Recognising the complexity of the underlying causes of OHCA in the community, we aimed to establish the clinical, pharmacological, environmental and genetic factors and their interactions that may cause OHCA. Methods and analysis: We set up a large-scale prospective community-based registry (AmsteRdam Resuscitation Studies, ARREST) in which we prospectively include all resuscitation attempts from OHCA in a large study region in the Netherlands in collaboration with Emergency Medical Services. Of all OHCA victims since June 2005, we prospectively collect medical history (through hospital and general practitioner), and current and previous medication use (through community pharmacy). In addition, we include DNA samples from OHCA victims with documented ventricular tachycardia/fibrillation during the resuscitation attempt since July 2007. Various study designs are employed to analyse the data of the ARREST registry, including case-control, cohort, case only and case-cross over designs. Ethics and dissemination: We describe the rationale, outline and potential results of the ARREST registry. The design allows for a stable and reliable collection of multiple determinants of OHCA, while assuring that the patient, lay-caregiver or medical professional is not hindered in any way. Such comprehensive data collection is required to unravel the complex basis of OHCA. Results will be published in peer-reviewed journals and presented at relevant scientific symposia.

Details

Language :
English
ISSN :
20533624
Database :
OpenAIRE
Journal :
Blom, M T, Van Hoeijen, D A, Bardai, A, Berdowski, J, Souverein, P C, De Bruin, M L, Koster, R W, De Boer, A & Tan, H L 2014, ' Genetic, clinical and pharmacological determinants of out-of-hospital cardiac arrest : Rationale and outline of the AmsteRdam Resuscitation Studies (ARREST) registry ', Open Heart, vol. 1, no. 1, e000112 . https://doi.org/10.1136/openhrt-2014-000112, Open Heart, 1(1):e000112. BMJ Publishing Group, Open Heart, 1(1). BMJ Publishing Group, Europe PubMed Central, Open heart, 1(1). BMJ Publishing Group, Open Heart, ResearcherID
Accession number :
edsair.doi.dedup.....4fc183bad7033d980ec1c613d1811164