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CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study
- Source :
- Nutrients, Nutrients, Vol 9, Iss 3, p 269 (2017), Nutrients; Volume 9; Issue 3; Pages: 269, Nutrients, 9(3):269
- Publication Year :
- 2016
-
Abstract
- Previous investigations have determined that some individuals have minimal or even ergolytic performance effects after caffeine ingestion. The aim of this study was to analyze the influence of the genetic variations of the CYP1A2 gene on the performance enhancement effects of ingesting a moderate dose of caffeine. In a double-blind randomized experimental design, 21 healthy active participants (29.3 ± 7.7 years) ingested 3 mg of caffeine per kg of body mass or a placebo in testing sessions separated by one week. Performance in the 30 s Wingate test, visual attention, and side effects were evaluated. DNA was obtained from whole blood samples and the CYP1A2 polymorphism was analyzed (rs762551). We obtained two groups: AA homozygotes (n = 5) and C-allele carriers (n = 16). Caffeine ingestion increased peak power (682 ± 140 vs. 667 ± 137 W; p = 0.008) and mean power during the Wingate test (527 ± 111 vs. 518 ± 111 W; p < 0.001) with no differences between AA homozygotes and C-allele carriers (p > 0.05). Reaction times were similar between caffeine and placebo conditions (276 ± 31 vs. 269 ± 71 milliseconds; p = 0.681) with no differences between AA homozygotes and C-allele carriers. However, 31.3% of the C-allele carriers reported increased nervousness after caffeine ingestion, while none of the AA homozygotes perceived this side effect. Genetic variations of the CYP1A2 polymorphism did not affect the ergogenic effects and drawbacks derived from the ingestion of a moderate dose of caffeine.
- Subjects :
- 0301 basic medicine
Male
cycling
5' Flanking Region
Pilot Projects
Anxiety
ergogenic aid
chemistry.chemical_compound
0302 clinical medicine
Genotype
Ingestion
Medicine
Attention
genetics
Whole blood
Nutrition and Dietetics
Homozygote
performance
side effects
Biochemistry
Visual Perception
Female
Caffeine
lcsh:Nutrition. Foods and food supply
Adult
medicine.medical_specialty
Heterozygote
Side effect
lcsh:TX341-641
Performance-Enhancing Substances
Placebo
Polymorphism, Single Nucleotide
Article
03 medical and health sciences
Young Adult
Double-Blind Method
Cytochrome P-450 CYP1A2
Internal medicine
Humans
Exercise
Alleles
Genetic Association Studies
Wingate test
030109 nutrition & dietetics
business.industry
CYP1A2
030229 sport sciences
Endocrinology
chemistry
Spain
Dietary Supplements
business
Food Science
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 9
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....4fba405ad4ef3affdf42555bd7e8769b