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Assessing the role of peripheral CD8 T cells in neurocognitive impairment in HIV-infected men who have sex with men: data from the MSM Neurocog Study
- Source :
- International journal of STDAIDS. 26(2)
- Publication Year :
- 2014
-
Abstract
- Studies have suggested CD8 lymphocytes may be a possible marker for inflammation, which is believed to be a contributing factor to neurocognitive impairment. Individuals enrolled in the MSM Neurocog Study were analysed. Those with depression, anxiety or mood disorders were excluded. Individuals with neurocognitive impairment were identified using the Brief NeuroCognitive Screen and compared to those with normal scores. CD4 and CD8 T cell values and CD4:CD8 ratios were compared between groups. In all, 144 men, aged 18–50 years, were included in the analysis. Twenty were diagnosed with neurocognitive impairment. We were unable to identify any significant difference between current, nadir or peak CD4 and CD8 counts. CD4:CD8 ratios and CD4:CD8 ratio inversion (
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
CD4-CD8 Ratio
HIV Infections
Dermatology
CD8-Positive T-Lymphocytes
Neuropsychological Tests
Men who have sex with men
Young Adult
Acquired immunodeficiency syndrome (AIDS)
Risk Factors
Internal medicine
Surveys and Questionnaires
London
medicine
Humans
Pharmacology (medical)
Homosexuality, Male
Depression (differential diagnoses)
Retrospective Studies
business.industry
Public Health, Environmental and Occupational Health
Middle Aged
medicine.disease
Infectious Diseases
Mood disorders
Immunology
Anxiety
medicine.symptom
business
Cognition Disorders
Neurocognitive
CD8
Subjects
Details
- ISSN :
- 17581052
- Volume :
- 26
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International journal of STDAIDS
- Accession number :
- edsair.doi.dedup.....4fb9289efbac6110283b1ffca2f15fb0