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Primate Cytomegaloviruses Encode and Express an IL-10-like Protein
- Source :
- Virology. 268(2):272-280
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- An open reading frame (ORF) with homology to interleukin-10 (IL-10) has been identified in rhesus cytomegalovirus (RhCMV). The IL-10-like protein is generated from a multispliced, polyadenylated early gene transcript encompassing part of the corresponding UL111A ORF of human CMV (HCMV). Immunological analyses confirm expression of the IL-10-like protein both in tissue culture and in RhCMV-infected rhesus macaques. Conserved ORFs were subsequently identified in human, baboon, and African green monkey CMV, and a fully processed transcript has been mapped in fibroblasts infected with the Towne strain of HCMV. The conservation of this previously unrecognized ORF suggests that the protein may play an essential role in primate CMV persistence and pathogenesis.
- Subjects :
- Gene Expression Regulation, Viral
DNA, Complementary
Genes, Viral
Protein Conformation
viruses
Molecular Sequence Data
Cytomegalovirus
Sequence alignment
Biology
Homology (biology)
Open Reading Frames
Viral Proteins
03 medical and health sciences
Exon
0302 clinical medicine
Virology
Chlorocebus aethiops
Animals
Humans
Amino Acid Sequence
ORFS
Peptide sequence
030304 developmental biology
Viral Structural Proteins
Genetics
0303 health sciences
COS cells
Sequence Homology, Amino Acid
virus diseases
Exons
Macaca mulatta
Introns
Interleukin-10
3. Good health
Open reading frame
COS Cells
Cytomegalovirus Infections
DNA, Viral
RNA, Viral
African Green Monkey
Sequence Alignment
Papio
030215 immunology
Subjects
Details
- ISSN :
- 00426822
- Volume :
- 268
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....4fb8916ba253257230996838f7f38f8e
- Full Text :
- https://doi.org/10.1006/viro.2000.0195