Back to Search
Start Over
Angiotensin II Type 1 Receptor Blocker Prevents Atrial Structural Remodeling in Rats with Hypertension Induced by Chronic Nitric Oxide Inhibition
- Source :
- Hypertension Research. 29:277-284
- Publication Year :
- 2006
- Publisher :
- Japanese Society of Hypertension, 2006.
-
Abstract
- The prevalence of atrial fibrillation (AF) increases in patients with hypertension. Angiotensin II is involved in structural atrial remodeling, which contributes to the onset and maintenance of AF in paced animal models. We investigated the role of angiotensin II in atrial structural remodeling in rats with hypertension. Ten-week-old male Wistar-Kyoto rats were randomly divided into 4 groups: a control group (no treatment), an Nomega-nitro-L-arginine methyl ester (L-NAME) group (administered L-NAME, an inhibitor of nitric oxide synthase, 1 g/l in drinking water), an L-NAME+candesartan group (L-NAME plus candesartan-an angiotensin II receptor blocker (ARB)-at 0.1 mg/kg/day), and an L-NAME + hydralazine group (L-NAME plus hydralazine at 120 mg/l in drinking water). Eight weeks after treatment, the L-NAME group showed significantly higher systolic blood pressure than the control group (197 +/- 12 vs.138 +/- 5 mmHg, p < 0.05). Candesartan or hydralazine with L-NAME reduced systolic blood pressure to baseline. Chronic inhibition of NO synthesis increased the extent of fibrosis and transforming growth factor-beta expression in atrial tissue, and both of these effects were prevented by candesartan, but not by hydralazine. Cardiac hypertrophy and dysfunction were induced in the L-NAME group, and these effects were also prevented by candesartan, but not by hydralazine. In contrast, the decrease in thrombomodulin expression in the atrial endocardium in hypertensive rats was restored by candesartan and hydralazine. The ARB prevented atrial structural remodeling, a possible contributing factor for the development of AF, in the hearts of rats with hypertension induced by long-term inhibition of NO synthesis.
- Subjects :
- Male
medicine.medical_specialty
Angiotensin receptor
Physiology
Thrombomodulin
Tetrazoles
Blood Pressure
Cardiomegaly
Nitric Oxide
Rats, Inbred WKY
Nitric oxide
chemistry.chemical_compound
Heart Rate
Internal medicine
Internal Medicine
medicine
Animals
Heart Atria
Enzyme Inhibitors
Antihypertensive Agents
biology
business.industry
Biphenyl Compounds
Atrial fibrillation
Hydralazine
medicine.disease
Angiotensin II
Rats
Nitric oxide synthase
Candesartan
NG-Nitroarginine Methyl Ester
Endocrinology
Blood pressure
chemistry
Hypertension
biology.protein
Benzimidazoles
Nitric Oxide Synthase
Cardiology and Cardiovascular Medicine
business
Angiotensin II Type 1 Receptor Blockers
medicine.drug
Subjects
Details
- ISSN :
- 13484214 and 09169636
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Hypertension Research
- Accession number :
- edsair.doi.dedup.....4fb51724703527866f378c09619a6ff7
- Full Text :
- https://doi.org/10.1291/hypres.29.277