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Alterations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) are found frequently in human colorectal tumours displaying either microsatellite stability (MSS) or instability (MSI)
- Source :
- Cancer Letters. 223:137-142
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Methylation of promoter regions and frameshift mutations in microsatellites of the coding sequence (CDS) of genes are frequently associated with loss of expression in microsatellite instable (MSI) colorectal carcinoma. In a panel of 40 MSI and 24 microsatellite stable (MSS) colorectal tumours as well as six cultured colorectal carcinoma cell lines hypermethylation of the TIMP3-promoter was found in 28% of MSI and 25% of MSS tumours, respectively. Additionally, three MSI tumours and one cell line displayed instability of a C7-repeat located in the CDS of the TIMP-3 gene. TIMP-3 fulfils all important criteria for being a target gene in the mutator pathway. Thus, TIMP-3 might be a factor of general importance for colorectal carcinogenesis.
- Subjects :
- Tissue Inhibitor of Metalloproteinase-3
Cancer Research
Colorectal cancer
Methylation
DNA Methylation
Biology
medicine.disease
Molecular biology
digestive system diseases
Frameshift mutation
Oncology
CpG site
DNA methylation
medicine
Animals
Humans
Microsatellite
Coding region
CpG Islands
RNA, Messenger
Colorectal Neoplasms
Frameshift Mutation
Promoter Regions, Genetic
Gene
Microsatellite Repeats
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 223
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....4fabd64b67cfc20b633bfbb0bbb96d66