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The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
- Source :
- Heliyon, Heliyon, Vol 5, Iss 6, Pp e01899-(2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Since the surface immunogenic protein (Sip) of group B streptococcus was identified, it's immunogenicity and its potential as a universal vaccine candidate has been evaluated extensively. We developed recombinant Sip protein and used it for monoclonal antibody generation to develop immunochromatographic test kit for GBS detection. The test of bacteria and culture media revealed the correlation between Sip protein expression and diagnosis discrepancy, which has never been reported. Furthermore, not only the surface accessibility of the Sip protein may vary from strains or serotypes; the secretion level of Sip protein may also vary.
- Subjects :
- 0301 basic medicine
Serotype
medicine.drug_class
Immunology
Monoclonal antibody
medicine.disease_cause
Microbiology
Biochemistry
Group B
Article
law.invention
03 medical and health sciences
0302 clinical medicine
law
medicine
Secretion
lcsh:Social sciences (General)
lcsh:Science (General)
Multidisciplinary
biology
Streptococcus
Immunogenicity
biology.organism_classification
030104 developmental biology
Recombinant DNA
lcsh:H1-99
030217 neurology & neurosurgery
Bacteria
lcsh:Q1-390
Subjects
Details
- Language :
- English
- ISSN :
- 24058440
- Volume :
- 5
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Heliyon
- Accession number :
- edsair.doi.dedup.....4fa71c38fdf36131d814ae8e9b3c47fc