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Differentiation potential and functional properties of a CD34‑CD133+ subpopulation of endothelial progenitor cells
- Publication Year :
- 2022
- Publisher :
- Universität des Saarlandes, 2022.
-
Abstract
- Endothelial progenitor cells (EPCs) promote angiogenesis and play an important role in myocardial and vascular repair after ischemia and infarction. EPCs consist of different subpopulations including CD34‑CD133+ EPCs, which are precursors of more mature CD34+CD133+ EPCs and functionally more active in terms of homing and endothelial regeneration. In the present study we analyzed the functional and differentiation abilities of CD34‑CD133+ EPCs. Isolation of EPC populations (CD34+CD133+, CD34‑CD133+) were performed by specific multi‑step magnetic depletion. After specific stimulation a significant higher adhesive and migrative capacity of CD34‑CD133+ cells could be detected compared to CD34+CD133+ cells (P
- Subjects :
- 0301 basic medicine
Cancer Research
Cell type
Angiogenesis
proliferation
CD34
Antigens, CD34
migration
Biochemistry
03 medical and health sciences
0302 clinical medicine
Cell Movement
Ischemia
Genetics
medicine
Humans
Regeneration
Cell Lineage
AC133 Antigen
Progenitor cell
Fibroblast
neoplasms
Molecular Biology
Endothelial Progenitor Cells
Neovascularization, Pathologic
Chemistry
Cell Differentiation
differentiation
Fibroblasts
Cell cycle
pluripotency
Cell biology
carbohydrates (lipids)
adhesion
030104 developmental biology
medicine.anatomical_structure
Oncology
Infarction
Apoptosis
030220 oncology & carcinogenesis
embryonic structures
cardiovascular system
Molecular Medicine
Endothelium, Vascular
circulatory and respiratory physiology
Homing (hematopoietic)
endothelial progenitor cell subpopulations
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4fa3e7b06dce8ad408e9f6577c062b5e
- Full Text :
- https://doi.org/10.22028/d291-38498