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Assessment of Gold Bio-Functionalization for Wide-Interface Biosensing Platforms
- Source :
- Sensors (Basel, Switzerland), Sensors, Vol 20, Iss 3678, p 3678 (2020), Sensors
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The continuous improvement of the technical potential of bioelectronic devices for biosensing applications will provide clinicians with a reliable tool for biomarker quantification down to the single molecule. Eventually, physicians will be able to identify the very moment at which the illness state begins, with a terrific impact on the quality of life along with a reduction of health care expenses. However, in clinical practice, to gather enough information to formulate a diagnosis, multiple biomarkers are normally quantified from the same biological sample simultaneously. Therefore, it is critically important to translate lab-based bioelectronic devices based on electrolyte gated thin-film transistor technology into a cost-effective portable multiplexing array prototype. In this perspective, the assessment of cost-effective manufacturability represents a crucial step, with specific regard to the optimization of the bio-functionalization protocol of the transistor gate module. Hence, we have assessed, using surface plasmon resonance technique, a sustainable and reliable cost-effective process to successfully bio-functionalize a gold surface, suitable as gate electrode for wide-field bioelectronic sensors. The bio-functionalization process herein investigated allows to reduce the biorecognition element concentration to one-tenth, drastically impacting the manufacturing costs while retaining high analytical performance.
- Subjects :
- Letter
Computer science
Process (engineering)
Interface (computing)
Nanotechnology
Biosensing Techniques
02 engineering and technology
lcsh:Chemical technology
010402 general chemistry
01 natural sciences
Biochemistry
Analytical Chemistry
law.invention
law
lcsh:TP1-1185
cost-effective biosensors
Electrical and Electronic Engineering
Electrodes
Instrumentation
Protocol (science)
lab-on-a-chip
Surface Plasmon Resonance
Lab-on-a-chip
biosensors
021001 nanoscience & nanotechnology
bio-functionalization optimization
Atomic and Molecular Physics, and Optics
0104 chemical sciences
3. Good health
Design for manufacturability
Electrode
Surface modification
Gold
0210 nano-technology
Biosensor
Subjects
Details
- ISSN :
- 14248220
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Sensors
- Accession number :
- edsair.doi.dedup.....4fa2c938b9ef1ffc578e7c599e38a2a9