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Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse
- Source :
- Brain Research Reviews. 58:121-135
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Drug abuse researchers have noted striking similarities between behaviors elicited by Pavlovian sign-tracking procedures and prominent symptoms of drug abuse. In Pavlovian sign-tracking procedures, repeated paired presentations of a small object (conditioned stimulus, CS) with a reward (unconditioned stimulus, US) elicits a conditioned response (CR) that typically consists of approaching the CS, contacting the CS, and expressing consummatory responses at the CS. Sign-tracking CR performance is poorly controlled and exhibits spontaneous recovery and long-term retention, effects that resemble relapse. Sign-tracking resembles psychomotor activation, a syndrome of behavioral responses evoked by addictive drugs, and the effects of sign-tracking on corticosterone levels and activation of dopamine pathways resemble the neurobiological effects of abused drugs. Finally, the neurobiological profile of individuals susceptible to sign-tracking resembles the pathophysiological profile of vulnerability to drug abuse, and vulnerability to sign-tracking predicts vulnerability to impulsive responding and alcohol self-administration. Implications of sign-tracking for models of drug addiction are considered.
- Subjects :
- Drug
Substance-Related Disorders
Dopamine
media_common.quotation_subject
Conditioning, Classical
Spontaneous recovery
Stimulus Salience
Article
Neural Pathways
medicine
Animals
Humans
Biogenic Monoamines
media_common
Psychomotor learning
General Neuroscience
Addiction
Classical conditioning
medicine.disease
Substance abuse
Neurology (clinical)
Corticosterone
Psychology
Neuroscience
Psychomotor Performance
Stress, Psychological
medicine.drug
Subjects
Details
- ISSN :
- 01650173
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Brain Research Reviews
- Accession number :
- edsair.doi.dedup.....4fa0434bf4737e6c0d504f6d2632ddc3