Efficacy of an anti-CD22 antibody-monomethyl auristatin E conjugate in a preclinical xenograft model of precursor B-cell acute lymphoblastic leukemia

Authors :: Yueju Li
Laurel A. Beckett
Jong Hee Chung
Emily Tuscano
Noriko Satake
Sakiko Yoshida
Joseph Tuscano
Connie P.M. Duong
Source :: Leukemia & lymphoma, vol 58, iss 5
Publication Year :: 2017
Publisher :: eScholarship, University of California, 2017.
Abstract: Precursor B-cell acute lymphoblastic leukemia (preB ALL) is the most common childhood cancer.[1,2] Despite improved overall progress in the treatment, patients with certain types of preB ALL have a...

Subjects :: 0301 basic medicine
Male
Cancer Research
Immunoconjugates
Lymphoblastic Leukemia
Sialic Acid Binding Ig-like Lectin 2
Drug Evaluation, Preclinical
chemistry.chemical_compound
Mice
0302 clinical medicine
Antineoplastic Agents, Immunological
hemic and lymphatic diseases
Monoclonal
Medicine
Molecular Targeted Therapy
Child
Oligopeptide
Tumor
biology
CD22
Antibodies, Monoclonal
Hematology
Preclinical
Immunological
Oncology
Monomethyl auristatin E
030220 oncology & carcinogenesis
Child, Preschool
Antibody
Oligopeptides
Cell Survival
Clinical Sciences
Immunology
Antineoplastic Agents
Article
Antibodies
Cell Line
03 medical and health sciences
Cell Line, Tumor
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Animals
Humans
Preschool
business.industry
Animal
B-cell acute lymphoblastic leukemia
Xenograft Model Antitumor Assays
Disease Models, Animal
030104 developmental biology
chemistry
Cell culture
Disease Models
Cancer research
biology.protein
Drug Evaluation
business
Conjugate

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