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Prognostic implications of EGFR and HER-2 alteration assessed by immunohistochemistry and silver in situ hybridization in gastric cancer patients following curative resection
- Source :
- Gastric Cancer. 17:402-411
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- The aim of this study was to use immunohistochemistry (IHC) and silver in situ hybridization (SISH) to evaluate alterations in EGFR and HER2 in gastric cancer in order to determine the relationship with prognosis in gastric cancer patients following curative resection.In this study, we analyzed EGFR and HER-2 status by IHC and SISH in 254 stage I-III gastric cancer patients who underwent curative surgery.Thirteen cases (2.48 %) showed EGFR alteration by IHC or SISH. EGFR alteration was associated with older age (P = 0.021), intestinal type (P = 0.040) and higher stage disease (P 0.001). The patients with operable state gastric cancer who had EGFR alteration had an unfavorable prognosis, and multivariate analysis confirmed that EGFR alteration was an independent unfavorable prognostic factor. Twenty-seven cases (10.6 %) showed HER-2 alteration by IHC or SISH. HER-2 alteration was associated with older age (P = 0.006), well or moderately differentiated histology (P 0.001) and intestinal type (P = 0.002).HER-2 alteration is not an independent prognostic factor for curatively resectable gastric cancer. We observed EGFR alteration in a subset of cases with operable state gastric cancer and determined that it was associated with an unfavorable prognosis.
- Subjects :
- Adult
Male
Curative resection
Cancer Research
Pathology
medicine.medical_specialty
Silver
Receptor, ErbB-2
In situ hybridization
Stomach Neoplasms
Surgical oncology
medicine
Humans
In Situ Hybridization
Aged
Neoplasm Staging
Aged, 80 and over
business.industry
digestive, oral, and skin physiology
Age Factors
Gastroenterology
Follow up studies
Cancer
General Medicine
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
ErbB Receptors
Oncology
Multivariate Analysis
Female
Neoplasm staging
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 14363305 and 14363291
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Gastric Cancer
- Accession number :
- edsair.doi.dedup.....4f8987febf4514507448a92377cd73a9