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T wave alternans in experimental myocardial infarction: time course and predictive value for the assessment of myocardial damage
- Source :
- Journal of electrocardiology. 46(3)
- Publication Year :
- 2012
-
Abstract
- Background T-wave alternans (TWA) is associated with prognosis after myocardial infarction (MI), however its link to the extent of ischemic injury has not been clarified. We analyzed the course of TWA and its relation to myocardial damage in experimental myocardial infarction. Methods In 21 pigs, infarction was induced by 40-minute long balloon inflation in LAD under continuous 12-lead ECG monitoring. TWA was assessed in a 32-beat sliding window, using periodic component analysis and the Laplacian Likelihood Ratio method. Myocardium at risk (MaR) and infarct size (IS) were evaluated by SPECT and magnetic resonance imaging respectively. Results TWA appeared at 7.2 ± 4.5 minutes of occlusion, reached its maximum at 12.7 ± 6.3 and lasted until 26.5 ± 9.2 minutes. The maximal level of TWA was associated with both MaR (r = 0.499, p = 0.035) and IS (r = 0.65, p = 0.004). Conclusion TWA magnitude is associated with both MaR and IS in experiment, which encourages further studies in clinical settings.
- Subjects :
- medicine.medical_specialty
Swine
Myocardial Infarction
Infarction
Sensitivity and Specificity
Electrocardiography
Heart Rate
Internal medicine
Occlusion
medicine
Animals
Myocardial infarction
Diagnosis, Computer-Assisted
Myocardial Stunning
medicine.diagnostic_test
business.industry
Reproducibility of Results
Magnetic resonance imaging
T wave alternans
medicine.disease
Infarct size
Prognosis
Predictive value
Time course
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15328430
- Volume :
- 46
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of electrocardiology
- Accession number :
- edsair.doi.dedup.....4f85c24b7abe8c297943d0ce13702b2e