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Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins
- Source :
- Cell. 68:341-352
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- The avidity of integrin CR3 (also known as α M β 2 , Mac-1, Mo-1, and CD11bCD18) may be reversibly altered without changes in the number of cell surface receptors. Here we describe a molecule termed integrin modulating factor (IMF-1), which controls CR3 avidity. Addition of IMF-1 to polymorphonuclear leukocytes (PMNs) or to purified CR3 causes enhanced binding of ligand. IMF-1 is not present in resting PMNs, but stimulation of cells results in a transient rise in IMF-1 content that parallels a transient rise in CR3 activity. We suggest that PMNs control adhesivity by controlling synthesis of IMF-1, which then acts as an allosteric activator of leukocyte integrins. IMF-1 is an acidic, amphiphilic molecule of M r 340 ± 16 that does not contain ester, phosphate, amide, sialic acid, or glycosidic or vicinal hydroxyl functionalities, but does contain a carbon-carbon double bond. These results suggest that IMF-1 is an unsaturated fatty acid or an isoprenoid acid.
- Subjects :
- Neutrophils
Fatty Acids
Allosteric regulation
Integrin
Macrophage-1 Antigen
hemic and immune systems
chemical and pharmacologic phenomena
Biology
Flow Cytometry
Ligand (biochemistry)
General Biochemistry, Genetics and Molecular Biology
Sialic acid
Kinetics
chemistry.chemical_compound
chemistry
Integrin alpha M
Biochemistry
Cell surface receptor
Cell Adhesion
Fatty Acids, Unsaturated
Biophysics
biology.protein
Tetradecanoylphorbol Acetate
Avidity
Unsaturated fatty acid
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....4f81294218f176fc4ad3434bcc425134