Additional file 1 of Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

Additional file 1: Figure S1. Functional enrichment analysis and largest connected component of the six CRISPR-Cas9-based SARS-CoV-2 host factor datasets. Figure S2. Network proximity results using different numbers of top genes from the CRISPR-Cas9-based SARS-CoV-2 host factor datasets. Figure S3. Single-cell level expression of AD blood markers in the PBMC samples of COVID-19 patients. Figure S4. Expression spectrum of the SARS-CoV-2 entry factors in the entorhinal cortex from Alzheimer’s disease patients and controls. Figure S5. Expression spectrum of the SARS-CoV-2 entry factors in individuals with different APOE genotypes. Figure S6. Expression of the key SARS-CoV-2 entry factors in different tissues. Figure S7. Expression of the key SARS-CoV-2 entry factors in different brain regions. Figure S8. Cumulative degree distribution of 964 innate immune genes, 14267 brain expressed genes, and 3383 brain specific genes.