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Cerebellar granule cell precursors can differentiate into astroglial cells
- Source :
- Proceedings of the National Academy of Sciences. 101:1211-1216
- Publication Year :
- 2004
- Publisher :
- Proceedings of the National Academy of Sciences, 2004.
-
Abstract
- During CNS development, multipotent neural stem cells give rise first to various kinds of specified precursor cells, which proliferate extensively before terminally differentiating into either neurons or glial cells. It is still not clear, however, whether the specified precursor cells are irreversibly determined to differentiate into their particular cell types. In this study, we show that isolated mouse cerebellar granule cell precursors from the outermost, proliferative zone of the external germinal layer can differentiate into astroglial cells when exposed to sonic hedgehog (Shh) and bone morphogenetic proteins. These induced cells initially expressed both glial fibrillary acidic protein and neuronal markers, but they then lost their neuronal markers and acquired S100-β, a marker of differentiated astroglial cells. These results indicate that at least some granule cell precursors are not irreversibly committed to neuronal development but can be induced to differentiate into astroglial cells by appropriate extracellular signals.
- Subjects :
- Cell type
Cerebellum
Cellular differentiation
Bone Morphogenetic Protein 2
Biology
Mice
Transforming Growth Factor beta
Precursor cell
Glial Fibrillary Acidic Protein
medicine
Animals
Hedgehog Proteins
Multidisciplinary
Glial fibrillary acidic protein
Stem Cells
Cell Differentiation
Biological Sciences
Neural stem cell
Cell biology
Mice, Inbred C57BL
P19 cell
medicine.anatomical_structure
Astrocytes
Bone Morphogenetic Proteins
Trans-Activators
biology.protein
Stem cell
Cell Division
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....4f6ce2591a6c9c8104d07a06e450abcd