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Single cryothermia applications of less than five minutes produce permanent cavotricuspid isthmus block in humans
- Source :
- Heart Rhythm. 1:594-599
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- The aim of this study was to compare single-3-minute (single-3) with double-3-minute (double-3) cryothermia applications for treatment of atrial flutter (AFL).Previous animal studies have indicated the need for a double 5-minute cryothermal application to create large and permanent lesions.Forty patients (56 +/- 13 years old) with typical AFL (cycle length 229 +/- 35 ms) were randomized to single-3 (n = 20) or double-3 (n = 20) cryothermia applications at each site along the cavotricuspid isthmus (CTI). Cryoablation was performed with the CryoCor cryoablation system. A successful procedure was defined as noninducibility of AFL with the concomitant presence of bidirectional CTI conduction block under isoproterenol infusion.All but 1 patient (95%) of the single-3 group and all patients (100%) of the double-3 group were successfully ablated. The number of sites needed to create isthmus conduction block was 9 +/- 4 (single-3) and 8 +/- 2 (double-3) (NS). Fluoroscopy time did not differ between the two groups (single-3: 31 +/- 14; double-3: 36 +/- 17 min, NS). The procedure time of the single-3 group was significantly shorter compared to the procedure time of the double-3 group (mean procedure duration 132 +/- 64 vs 159 +/- 50 min, P.04). After a mean follow-up of 11.7 +/- 4.7 months, two recurrences of AFL occurred in the double-3 group.Single cryothermia applications of 3 minutes produce permanent CTI conduction block in patients with typical AFL and significantly reduce procedure duration.
- Subjects :
- Male
Cavotricuspid isthmus
medicine.medical_treatment
Block (permutation group theory)
Catheter ablation
Cryosurgery
Heart Conduction System
Physiology (medical)
Atrial Fibrillation
medicine
Humans
business.industry
Atrial fibrillation
Cryoablation
Middle Aged
medicine.disease
Electrophysiology
Atrial Flutter
Anesthesia
Concomitant
Female
Tricuspid Valve
Venae Cavae
Electrical conduction system of the heart
Cardiology and Cardiovascular Medicine
business
Nuclear medicine
Atrial flutter
Subjects
Details
- ISSN :
- 15475271
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Heart Rhythm
- Accession number :
- edsair.doi.dedup.....4f64c2f8f7a2f40707ecf92446507eca