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A Case-CrossovEr study deSign to inform tailored interventions to prevent disease progression in Acute Pancreatitis (ACCESS-AP) - study design and population
- Source :
- Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 21(7)
- Publication Year :
- 2021
-
Abstract
- Background/Objectives Alcohol is the most common etiology of recurrent acute pancreatitis and chronic pancreatitis. The extent and timing of drinking that increases the transient risk of acute pancreatitis is yet unknown. Methods We designed a case-crossover study to determine the effective hazard period of drinking in relation to episodes of pancreatitis. We aim to evaluate the dose-response relationship between excess drinking and pancreatitis comparing the extent of drinking during case and control periods from the same individual. We aim to recruit 160 patients hospitalized with acute pancreatitis, whose AUDIT-C score reaches 3 or higher. Interviews of each enrolled patient to define their 15-day history of alcohol consumption employing the timeline follow-back method. Long-term drinking and smoking will be investigated as modifiers of the impact of short-term excess drinking. Patients are followed-up for evaluation of usual alcohol consumption during asymptomatic periods following the index hospitalization. Blood and urine specimens are collected while the patients are hospitalized and during a standard-of-care follow-up visit. Results We have recruited 31 patients to date, with a median age of 33 years. Females and non-White participants make up 26% and 35% of the enrolled population, respectively. Forty-eight % of patients have had a prior history of acute pancreatitis. Conclusions Our study will shed light on the impact of short-term changes in drinking on triggering acute pancreatitis. It will provide data on other covarying factors of drinking and behaviors changes after acute pancreatitis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Alcohol Drinking
Pancreatitis, Alcoholic
Endocrinology, Diabetes and Metabolism
Population
Asymptomatic
Cigarette Smoking
Health Risk Behaviors
03 medical and health sciences
0302 clinical medicine
Recurrence
Risk Factors
Internal medicine
Epidemiology
medicine
Humans
education
education.field_of_study
Cross-Over Studies
Hepatology
business.industry
Gastroenterology
medicine.disease
Crossover study
Diet
Research Design
030220 oncology & carcinogenesis
Case-Control Studies
Sample Size
Tailored interventions
Etiology
Disease Progression
Pancreatitis
Acute pancreatitis
030211 gastroenterology & hepatology
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 14243911
- Volume :
- 21
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
- Accession number :
- edsair.doi.dedup.....4f646c487ae9160a69e053afc927cfcb