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Use of computed tomography assessed kidney length to predict split renal GFR in living kidney donors
- Source :
- European radiology. 27(2)
- Publication Year :
- 2015
-
Abstract
- Screening of living kidney donors may require scintigraphy to split glomerular filtration rate (GFR). To determine the usefulness of computed tomography (CT) to split GFR, we compared scintigraphy-split GFR to CT-split GFR. We evaluated CT-split GFR as a screening test to detect scintigraphy-split GFR lower than 40 mL/min/1.73 m2/kidney. This was a monocentric retrospective study on 346 potential living donors who had GFR measurement, renal scintigraphy, and CT. We predicted GFR for each kidney by splitting GFR using the following formula: Volume-split GFR for a given kidney = measured GFR*[volume of this kidney/(volume of this kidney + volume of the opposite kidney)]. The same formula was used for length-split GFR. We compared length- and volume-split GFR to scintigraphy-split GFR at donation and with a 4-year follow-up. A better correlation was observed between length-split GFR and scintigraphy-split GFR (r = 0.92) than between volume-split GFR and scintigraphy-split GFR (r = 0.89). A length-split GFR threshold of 45 mL/min/1.73 m2/kidney had a sensitivity of 100 % and a specificity of 75 % to detect scintigraphy-split GFR less than 40 mL/min/1.73 m2/kidney. Both techniques with their respective thresholds detected living donors with similar eGFR evolution during follow-up. Length-split GFR can be used to detect patients requiring scintigraphy. • Excellent correlation between kidney length and scintigraphy predicted GFR • Kidney length screening detects all donors with GFR lower than 40 mL/min/1.73 m 2 • Kidney length screening can replace scintigraphy screening.
- Subjects :
- Male
medicine.medical_specialty
Screening test
030232 urology & nephrology
Urology
Renal function
Computed tomography
urologic and male genital diseases
Scintigraphy
Kidney
Renal scintigraphy
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
medicine
Living Donors
Humans
Radiology, Nuclear Medicine and imaging
Radionuclide imaging
Radionuclide Imaging
reproductive and urinary physiology
Kidney transplantation
Retrospective Studies
medicine.diagnostic_test
urogenital system
business.industry
General Medicine
Middle Aged
medicine.disease
Kidney Transplantation
female genital diseases and pregnancy complications
medicine.anatomical_structure
Female
Radiology
business
Tomography, X-Ray Computed
Follow-Up Studies
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 14321084
- Volume :
- 27
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- European radiology
- Accession number :
- edsair.doi.dedup.....4f644b1235e37cb3f3c0499602faceed