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Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults
- Source :
- Journal of Alzheimer's disease 52(2), 661-672 (2016). doi:10.3233/JAD-151084
- Publication Year :
- 2016
-
Abstract
- Increasing evidence suggests that Alzheimer's disease (AD) sufferers show region-specific reductions in cerebral glucose metabolism, as measured by [18F]-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET). We investigated preclinical disease stage by cross-sectionally examining the association between global cognition, verbal and visual memory, and 18F-FDG PET standardized uptake value ratio (SUVR) in 43 healthy control individuals, subsequently focusing on differences between subjective memory complainers and non-memory complainers. The 18F-FDG PET regions of interest investigated include the hippocampus, amygdala, posterior cingulate, superior parietal, entorhinal cortices, frontal cortex, temporal cortex, and inferior parietal region. In the cohort as a whole, verbal logical memory immediate recall was positively associated with 18F-FDG PET SUVR in both the left hippocampus and right amygdala. There were no associations observed between global cognition, delayed recall in logical memory, or visual reproduction and 18F-FDG PET SUVR. Following stratification of the cohort into subjective memory complainers and non-complainers, verbal logical memory immediate recall was positively associated with 18F-FDG PET SUVR in the right amygdala in those with subjective memory complaints. There were no significant associations observed in non-memory complainers between 18F-FDG PET SUVR in regions of interest and cognitive performance. We observed subjective memory complaint-specific associations between 18F-FDG PET SUVR and immediate verbal memory performance in our cohort, however found no associations between delayed recall of verbal memory performance or visual memory performance. It is here argued that the neural mechanisms underlying verbal and visual memory performance may in fact differ in their pathways, and the characteristic reduction of 18F-FDG PET SUVR observed in this and previous studies likely reflects the pathophysiological changes in specific brain regions that occur in preclinical AD.
- Subjects :
- 0301 basic medicine
Male
physiology [Hippocampus]
Hippocampus
metabolism [Hippocampus]
Neuropsychological Tests
0302 clinical medicine
Parietal Lobe
metabolism [Amygdala]
Temporal cortex
General Neuroscience
Brain
Cognition
General Medicine
Amygdala
Psychiatry and Mental health
Clinical Psychology
metabolism [Glucose]
medicine.anatomical_structure
Female
Psychology
metabolism [Parietal Lobe]
Gyrus Cinguli
03 medical and health sciences
physiology [Brain]
Visual memory
Fluorodeoxyglucose F18
metabolism [Gyrus Cinguli]
metabolism [Fluorodeoxyglucose F18]
medicine
Humans
ddc:610
Effects of sleep deprivation on cognitive performance
Aged
physiology [Parietal Lobe]
physiology [Gyrus Cinguli]
physiology [Amygdala]
030104 developmental biology
Cross-Sectional Studies
Glucose
Acoustic Stimulation
metabolism [Brain]
physiology [Mental Recall]
Posterior cingulate
Positron-Emission Tomography
Mental Recall
Geriatrics and Gerontology
Verbal memory
Neuroscience
030217 neurology & neurosurgery
Photic Stimulation
Subjects
Details
- ISSN :
- 18758908
- Volume :
- 52
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....4f642bb1b8a9ca1132a2f89a5562096a