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Comparison with Various Parts ofBroussonetia papyriferaas to the Antinociceptive and Anti-Inflammatory Activities in Rodents
- Source :
- Bioscience, Biotechnology, and Biochemistry. 72:2377-2384
- Publication Year :
- 2008
- Publisher :
- Oxford University Press (OUP), 2008.
-
Abstract
- This study compared the antinociceptive and anti-inflammatory effects of various parts of Broussonetia papyrifera (L.) L'Herit. ex Vent. (BP, Moraceae) by chemical-induced pain and inflammation in rodents. All BP parts (1 and 2 g/kg, p.o.) effectively inhibited writhing responses induced by 1% acetic acid. The BP radix, leaf, and fruit effectively inhibited the late-phase licking responses caused by 1% formalin. But only the BP radix and fruit reduced the edema induced by 1% carrageenan at 1-2 h. Furthermore, the BP radix reduced the abdominal Evan's blue extravasations caused by inflammatory mediators, including serotonin and sodium nitroprusside. Finally, the radix had the highest contents of betulin and betulinic acid among all BP parts. In conclusion, the radix is the better medicinal BP part possessing antinociceptive and antiinflammatory effects, and its anti-inflammatory effects are partially related to the inhibition of vascular permeability via autocrines and nitric oxide.
- Subjects :
- Male
medicine.drug_class
Anti-Inflammatory Agents
Pain
Pharmacology
Carrageenan
Plant Roots
Applied Microbiology and Biotechnology
Biochemistry
Anti-inflammatory
Analytical Chemistry
law.invention
Capillary Permeability
Rats, Sprague-Dawley
Mice
chemistry.chemical_compound
law
Betulinic acid
Botany
medicine
Animals
Edema
Radix
Molecular Biology
Pain Measurement
Analgesics
Mice, Inbred ICR
Betulin
Dose-Response Relationship, Drug
biology
Plant Extracts
Chemistry
Organic Chemistry
General Medicine
Broussonetia
Moraceae
biology.organism_classification
Rats
Plant Leaves
Fruit
Phytotherapy
Biotechnology
Subjects
Details
- ISSN :
- 13476947 and 09168451
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Bioscience, Biotechnology, and Biochemistry
- Accession number :
- edsair.doi.dedup.....4f5d7b228456c6bd35b7759a9fbd855a