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Source of pain and primitive dysfunction in migraine: an identical site?
- Publication Year :
- 1989
-
Abstract
- Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by nitroglycerin in seven out of 10 patients versus no patient in the placebo group. Subsequently 20 migraine patients, who developed an early onset attack with frontotemporal nitroglycerin, received the drug in a second induction test at other body areas. No early onset migraine was observed. Thus the migraine-inducing effect of nitroglycerin seems to depend on direct stimulation of the habitual site of pain, suggesting that the frontotemporal region is of crucial importance in the development of a migraine crisis. This is not consistent with a CNS origin of migraine attack.
- Subjects :
- Adult
Male
Migraine Disorders
Placebo
Administration, Cutaneous
Placebo group
Temporal lobe
Double blind study
Ointments
Nitroglycerin
Double-Blind Method
medicine
Humans
Randomized Controlled Trials as Topic
business.industry
Middle Aged
medicine.disease
Pathophysiology
Temporal Lobe
Frontal Lobe
Psychiatry and Mental health
Migraine
Frontal lobe
One sided
Anesthesia
Surgery
Female
Neurology (clinical)
business
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4f4279f6a995f19e9d543fd800662867