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The ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signaling

Authors :
Anésia A. Santos
Elizabeth P. B. Fontes
Carolina S. Rocha
João Paulo Machado
Source :
LOCUS Repositório Institucional da UFV, Universidade Federal de Viçosa (UFV), instacron:UFV
Publication Year :
2008

Abstract

The NIK (NSP-interacting kinase)-mediated antiviral signaling pathway was identified as a virulence target of the begomovirus nuclear shuttle protein (NSP). Here, we further characterized this layer of plant innate defense by identifying the ribosomal protein L10 (rpL10), a QM-like protein, as a downstream effector of the antiviral signaling. Although both ribosomal proteins rpL10 and rpL18 were found to associate with NIK1 through yeast two-hybrid screening, the NIK receptors specifically phosphorylated rpL10 in vitro. Furthermore, loss of rpL10 function significantly increased susceptibility to begomovirus infection, recapitulating the phenotype of nik knockout lines. Our results genetically linked rpL10 to the NIK-mediated antiviral signaling.

Details

ISSN :
10960341
Volume :
380
Issue :
2
Database :
OpenAIRE
Journal :
Virology
Accession number :
edsair.doi.dedup.....4f363b3707d089ef270e6e20320ecb50