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The ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signaling
- Source :
- LOCUS Repositório Institucional da UFV, Universidade Federal de Viçosa (UFV), instacron:UFV
- Publication Year :
- 2008
-
Abstract
- The NIK (NSP-interacting kinase)-mediated antiviral signaling pathway was identified as a virulence target of the begomovirus nuclear shuttle protein (NSP). Here, we further characterized this layer of plant innate defense by identifying the ribosomal protein L10 (rpL10), a QM-like protein, as a downstream effector of the antiviral signaling. Although both ribosomal proteins rpL10 and rpL18 were found to associate with NIK1 through yeast two-hybrid screening, the NIK receptors specifically phosphorylated rpL10 in vitro. Furthermore, loss of rpL10 function significantly increased susceptibility to begomovirus infection, recapitulating the phenotype of nik knockout lines. Our results genetically linked rpL10 to the NIK-mediated antiviral signaling.
- Subjects :
- Ribosomal Proteins
Ribosomal Protein L10
Virulence Factors
Arabidopsis
Ribosomal protein L10
Virulence
Biology
Viral Proteins
Ribosomal protein
Virology
Two-Hybrid System Techniques
Protein Interaction Mapping
Phosphorylation
Receptor
Receptor-like kinase
Plant Diseases
Plant Proteins
Kinase
Effector
Arabidopsis Proteins
Phenotype
Molecular biology
Begomovirus
Signal transduction
Antiviral signaling
Protein Kinases
NIK receptor
Signal Transduction
Subjects
Details
- ISSN :
- 10960341
- Volume :
- 380
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....4f363b3707d089ef270e6e20320ecb50