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Effects of coenzyme Q10 on salivary secretion
- Source :
- Clinical biochemistry. 44(8-9)
- Publication Year :
- 2010
-
Abstract
- Objectives Dry mouth is a condition associated with reduced salivary secretion and is thought to be related to aging. This study was conducted to test whether reduced (ubiquinol) or oxidized (ubiquinone) forms of CoQ10 affect salivary secretion and salivary CoQ10 content before and after treatment. Design and methods Sixty-six patients were given either ubiquinol or ubiquinone orally at a dosage of 100 mg/day, or a placebo for 1 month, and salivary secretion and salivary CoQ10 content were analyzed before and after treatment. Results Both parameters were significantly improved following treatment with either form of CoQ10, suggesting the effectiveness of CoQ10 in attenuating dry mouth symptoms. Conclusion CoQ10 was locally detected in salivary glands, suggesting that orally administered CoQ10 was transported to the salivary glands via the blood stream and exerted its activity, improving salivary secretion.
- Subjects :
- Male
medicine.medical_specialty
Saliva
Ubiquinol
Antioxidant
Ubiquinone
medicine.medical_treatment
Clinical Biochemistry
Administration, Oral
Biology
Placebo
Antioxidants
chemistry.chemical_compound
Internal medicine
medicine
Humans
Aged
Coenzyme Q10
General Medicine
Middle Aged
Dry mouth
Endocrinology
Salivary secretion
chemistry
Female
medicine.symptom
Salivation
After treatment
Subjects
Details
- ISSN :
- 18732933
- Volume :
- 44
- Issue :
- 8-9
- Database :
- OpenAIRE
- Journal :
- Clinical biochemistry
- Accession number :
- edsair.doi.dedup.....4f235993e169e8b06d88ce259b75904d