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Cytoplasmic versus nuclear THR alpha expression determines survival of ovarian cancer patients
- Source :
- Journal of Cancer Research and Clinical Oncology
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Purpose Thyroid hormone receptors (THR) have manifold functions and are involved in the carcinogenesis of several tumor types. Within this study, we aimed to investigate the expression pattern (nuclear versus cytoplasmic) of the THR alpha and its impact on patients survival in ovarian cancer (OvCa). Methods The presence of the thyroid hormone receptors THRα, THRα1 and − 2 was investigated in 156 ovarian cancer samples using immunohistochemistry (IHC) using semi-quantitative immunoreactivity (IR) scores and correlated with clinical, pathological data, subtype of ovarian cancer, clinical data, staining of 20 already described OvCa marker proteins and overall survival (OS). Results Among all subtypes of OvCa, clear cell carcinomas showed the highest THRα expression. Furthermore, nuclear THRα was associated with a reduced survival in this subtype. However, nuclear expressed THRα1 turned out to be a positive prognosticator for all subtypes of OvCa patients. Nuclear THRα2 is a positive prognosticator for OvCa patients of the serous subtype. In contrast, cytoplasmic expression THRα2 was associated with a reduced OS in all subtypes of OvCa patients; while, cytoplasmic expression of THRα1 is associated with reduced OS in mucinous OvCa patients only. In addition, THRα expression correlates with gonadotropin receptors, steroid hormone receptors, TA-MUC1 and glycodelin. Conclusion Depending on nuclear or cytoplasmic expression, our study shows that THRα and its isoforms 1 and 2 provide different prognostic information for ovarian cancer patients. Further investigations should analyze if THRs may represent new endocrine targets for the treatment of ovarian cancer.
- Subjects :
- 0301 basic medicine
Cytoplasm
Cancer Research
endocrine system diseases
medicine.medical_treatment
Carcinoma, Ovarian Epithelial
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Ovarian cancer
medicine
Humans
Overall survival
ddc:610
Receptor
Thyroid hormone receptor
Aged
Aged, 80 and over
Cell Nucleus
Ovarian Neoplasms
business.industry
Nuclear versus cytoplasmic
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
female genital diseases and pregnancy complications
Survival Rate
Serous fluid
Steroid hormone
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cancer research
Female
Original Article – Cancer Research
Carcinogenesis
business
Clear cell
Thyroid Hormone Receptors alpha
Subjects
Details
- ISSN :
- 14321335 and 01715216
- Volume :
- 146
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer Research and Clinical Oncology
- Accession number :
- edsair.doi.dedup.....4f20cc84af541340cfd5a313fdd0f350