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Epidemiology for primary brain tumors: a nationwide population-based study
- Source :
- Journal of Neuro-Oncology, Journal of Neuro-Oncology, 2017, 131 (3), pp.525-546. ⟨10.1007/s11060-016-2318-3⟩, Journal of Neuro-Oncology, Springer Verlag, 2017, 131 (3), pp.525-546. ⟨10.1007/s11060-016-2318-3⟩
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- International audience; Primary central nervous system tumors (PCNST) are rare tumors responsible for high mortality and morbidity. Their epidemiology is poorly known, and clinical data are scarcely analyzed at a national level. In this study, we aimed at providing descriptive epidemiological data and incidence rates for all histological subtypes of PCNST according to the WHO classification. We conducted a nationwide population-based study of all newly diagnosed and histologically confirmed PCNST in France, between 2006 and 2011. A total of 57,816 patients were included: male 46.4%, median age at diagnosis 56 years old (range 0-99). For all newly diagnosed PCNST with histological confirmation the crude incidence rate was 15.5/105 per 100,000 person-years. To enable international comparisons, standardized rates were calculated: 14.1/105 (population of reference: USA), 14.5/105 (population of reference: Europe), and 12.0/105 (population of reference: world). 23.4% of samples were cryopreserved. Resection was performed in 79.1% of cases. Results are detailed (incidence rate, sex ratio, median age at diagnosis, number of cryopreserved samples, and type of surgery) for each of the 143 histological subtypes of PCNST, including all rare tumors. For example, incidence rates (population of reference: USA) were 0.018/105 for anaplastic gangliogliomas, 0.054/105 for malignant meningiomas, and 0.036/105 for hemangiopericytomas. Our study is the first to describe incidence rates and epidemiological data for all histological subtypes of PCNST, including rare tumors, at a national level. Its methodology ensures the exhaustiveness of the data collection for histologically-proven cases. Histological population-based studies have many perspectives in the field of clinical epidemiology and research.
- Subjects :
- Male
Cancer Research
Pediatrics
Pathology
Neurology
Databases, Factual
Epidemiology
0302 clinical medicine
Primary Brain Tumors
Child
Neuropathology
Aged, 80 and over
education.field_of_study
Brain Neoplasms
Incidence (epidemiology)
Incidence
Middle Aged
3. Good health
Oncology
030220 oncology & carcinogenesis
Child, Preschool
Female
Standardized rate
France
Sex ratio
Adult
medicine.medical_specialty
Adolescent
Population
Brain tumor
[SDV.CAN]Life Sciences [q-bio]/Cancer
Database
03 medical and health sciences
Young Adult
Neuro-oncology
medicine
Humans
education
Aged
business.industry
Infant, Newborn
Infant
medicine.disease
Neurology (clinical)
business
030217 neurology & neurosurgery
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0167594X and 15737373
- Database :
- OpenAIRE
- Journal :
- Journal of Neuro-Oncology, Journal of Neuro-Oncology, 2017, 131 (3), pp.525-546. ⟨10.1007/s11060-016-2318-3⟩, Journal of Neuro-Oncology, Springer Verlag, 2017, 131 (3), pp.525-546. ⟨10.1007/s11060-016-2318-3⟩
- Accession number :
- edsair.doi.dedup.....4f0aa1ad9bd7c264ab2ce25a467d9b57