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Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats
- Source :
- Basic and Clinical Neuroscience, Vol 8, Iss 1, Pp 37-42 (2017), Basic and Clinical Neuroscience
- Publication Year :
- 2017
- Publisher :
- Iran University of Medical Sciences, 2017.
-
Abstract
- Introduction Glabrous skin and hairy skin are innervated by different types of noxious fibers. However, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin. Methods In this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into either glabrous skin (plantar surface) of the hind paw or hairy skin of the hind limb in adult rats. Results A typical biphasic nociceptive response was seen after formalin injection into the plantar surface of the hind paw. A brief interphase separates the first and second phases where nociceptive behaviors were barely spotted. However, following subcutaneous injection into the hairy skin nociceptive behaviors were only seen after 10 minutes of formalin injection, which correlates in time with the second phase of the formalin response. First phase nociceptive behaviors were never seen with hairy skin injection, even following multiple injections of formalin. Conclusion These data suggest that nociceptive behaviors and spinal responses induced by formalin injections to glabrous and hairy skin areas are different, and that the first and second phases may be mediated through different noxious afferent fibers.
- Subjects :
- Nociception
Pathology
medicine.medical_specialty
Glabrous skin
Tonic pain
Plantar surface
Hindlimb
030226 pharmacology & pharmacy
lcsh:RC321-571
03 medical and health sciences
Cellular and Molecular Neuroscience
Subcutaneous injection
0302 clinical medicine
medicine
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Clinical neuroscience
integumentary system
Hairy skin
Formalin test
Inflammatory pain
Research Papers
Neurology (clinical)
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 22287442
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Basic and Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....4efedf9cfb7f9d1cb0fd3a8a8e18419a