Handheld Point-of-Care System for Rapid Detection of SARS-CoV-2 Extracted RNA in under 20 min

Authors :: Wendy S. Barclay
Frances Bolt
Jesus Rodriguez-Manzano
Kenny Malpartida-Cardenas
Alison Holmes
Luca Miglietta
Matthew L. Cavuto
Pantelis Georgiou
Giovanni Satta
Rebecca Penn
Nicolas Moser
Paul Randell
Ivana Pennisi
Frances Davies
Ahmad Moniri
Imperial College COVID-19 Research Fund
National Institute for Health Research
Source :: ACS Central Science, ACS Central Science, Vol 7, Iss 2, Pp 307-317 (2021)
Publication Year :: 2021
Publisher :: American Chemical Society (ACS), 2021.
Abstract: The COVID-19 pandemic is a global health emergency characterized by the high rate of transmission and ongoing increase of cases globally. Rapid point-of-care (PoC) diagnostics to detect the causative virus, SARS-CoV-2, are urgently needed to identify and isolate patients, contain its spread and guide clinical management. In this work, we report the development of a rapid PoC diagnostic test (<br />A CMOS-based point-of-care diagnostic platform for isothermal amplification/detection of SARS-CoV-2 RNA within 20 min coupled to a smartphone for data visualization and geolocalization is presented.

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