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Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles
- Source :
- Molecular medicine reports. 20(3)
- Publication Year :
- 2018
-
Abstract
- Autoimmunity may serve a role in the pathological features of a subgroup of patients with chronic obstructive pulmonary disease (COPD); however, in immunological subgroups of COPD patients, the interrelationships between airway and circulating autoantibody responses, and clinical parameters, remain unclear. The present study was undertaken to evaluate these interrelationships in various immunological subgroups of COPD patients. Sputum supernatant and serum obtained from 102 patients with stable COPD were assayed for the presence of immunoglobulin G antibodies against ten autoantigens via Luminex multiplex technology. Hierarchical clustering based on principal components was performed on autoantibody profiles to classify patients into clusters. Network‑based and module analyses were conducted to explore interrelationships among autoantibodies and clinical variables in each cluster. Topological characteristics were compared between clusters. Unsupervised clustering identified four clusters: No significant differences in the majority of clinical characteristics were observed among clusters. In cluster 1, retrospective exacerbation was only positively associated with COPD assessment test score. Lung functions (predicted % of forced expiratory volume in 1 sec and maximal mid‑expiratory flow) were negatively associated with exacerbation risk only in cluster 2. Sputum autoantibodies (against U1 small nuclear ribonucleoprotein, proteinase‑3 and Ro/Sjogren syndrome type A antigen) were negatively associated with exacerbation risks in cluster 2, but positively associated in cluster 3. The four networks also exhibited distinct topological properties. In COPD, autoantibody responses were heterogeneous and differentially associated with exacerbation risk in certain subgroups; their dual character should be considered in future research.
- Subjects :
- 0301 basic medicine
Male
Cancer Research
Exacerbation
medicine.disease_cause
Biochemistry
Immunoglobulin G
Autoimmunity
03 medical and health sciences
Pulmonary Disease, Chronic Obstructive
0302 clinical medicine
Genetics
medicine
Cluster Analysis
Humans
Molecular Biology
Pathological
Aged
Autoantibodies
COPD
Principal Component Analysis
biology
business.industry
Autoantibody
Sputum
Middle Aged
medicine.disease
respiratory tract diseases
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Immunology
biology.protein
Molecular Medicine
Female
medicine.symptom
business
Small nuclear ribonucleoprotein
Subjects
Details
- ISSN :
- 17913004
- Volume :
- 20
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Molecular medicine reports
- Accession number :
- edsair.doi.dedup.....4efaabd8834901f9b041634df11e8eab