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To lie or not to lie: Super-relaxing with myosins
- Source :
- eLife, Vol 10 (2021), eLife
- Publication Year :
- 2021
- Publisher :
- eLife Sciences Publications, Ltd, 2021.
-
Abstract
- Since the discovery of muscle in the 19th century, myosins as molecular motors have been extensively studied. However, in the last decade, a new functional super-relaxed (SRX) state of myosin has been discovered, which has a 10-fold slower ATP turnover rate than the already-known non-actin-bound, disordered relaxed (DRX) state. These two states are in dynamic equilibrium under resting muscle conditions and are thought to be significant contributors to adaptive thermogenesis in skeletal muscle and can act as a reserve pool that may be recruited when there is a sustained demand for increased cardiac muscle power. This report provides an evolutionary perspective of how striated muscle contraction is regulated by modulating this myosin DRX↔SRX state equilibrium. We further discuss this equilibrium with respect to different physiological and pathophysiological perturbations, including insults causing hypertrophic cardiomyopathy, and small-molecule effectors that modulate muscle contractility in diseased pathology.
- Subjects :
- QH301-705.5
Structural Biology and Molecular Biophysics
Science
Myosin
Review Article
Myosins
General Biochemistry, Genetics and Molecular Biology
Contractility
Super-relaxed state
Biochemistry and Chemical Biology
Mavacamten
Molecular motor
medicine
Animals
Humans
Biology (General)
Muscle, Skeletal
Dynamic equilibrium
General Immunology and Microbiology
Chemistry
General Neuroscience
Cardiac muscle
Skeletal muscle
Thermogenesis
General Medicine
Striated muscle contraction
Hypertrophic cardiomyopathy
Cell biology
medicine.anatomical_structure
Interacting heads motif
Medicine
medicine.symptom
Muscle Contraction
Muscle contraction
Subjects
Details
- ISSN :
- 2050084X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....4eed07fea41413273d3a085675e15138