Additional file 2 of Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis

Additional file 2: Fig. s2. Scores of melanocortin-1 receptor (MC1R) immunostaining in skin sections. The staining intensity of MC1R in skin samples from healthy subjects (n = 30), dcSSc patients (n = 50), and lcSSc (n = 10) patients was graded from 0 to 3. Qualitative assessment was performed by assigning a score based on staining intensity after identifying each stained cell type and tissue element. No staining, 0; faint staining, 0.5; light staining, 1; moderate staining, 2; dark staining: 3. All values are expressed as an individual plot dot and the mean ± SEM.