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Relationship between Mayo endoscopic score and histological scores in ulcerative colitis: A prospective study
- Source :
- JGH Open: An Open Access Journal of Gastroenterology and Hepatology, JGH Open, Vol 4, Iss 3, Pp 382-386 (2020)
- Publication Year :
- 2018
-
Abstract
- Background The Mayo endoscopic score (MES) remains the most commonly used index in clinical practice, as well as in various clinical trials. Recently, two validated histological indices (Nancy Index [NI] and Robert Histological Index [RHI]) have been developed for ulcerative colitis (UC). We aim to study the relationship between MES with NI, RHI, and the established Geboes Index (GI) in patients with UC. Methods This was a prospective singleācenter study. MES was documented from the most involved area. Biopsy was taken from the same area and reported by a single gastrointestinal histopathologist who was blinded to the endoscopic score. Histological activity was reported using GI, NI, and RHI. Statistical analysis was performed using Spearman's correlation coefficient and Cohen's kappa coefficient using SPSS version 23. Results Median age of patients with UC (n = 96) was 36 years. Seventeen patients were in endoscopic remission (MES 0/1). Correlation coefficient between MES and GI/NI/RHI was only weak to moderate (rho = 0.381/0.389/0.442, respectively; P<br />In the era of mucosal and histological healing, it is of utmost importance to understand the relationship between endoscopic and histological scores. In our study, we have shown that the endoscopic score is only moderately correlated with histological scores. Agreement between endoscopic and histological remission is also weak. A better endoscopic scoring system is needed for defining endoscopic remission.
- Subjects :
- medicine.medical_specialty
animal structures
Nancy Index
Robert Histological Index
RC799-869
Gastroenterology
03 medical and health sciences
Mayo endoscopic score
0302 clinical medicine
Internal medicine
Biopsy
medicine
In patient
Statistical analysis
Prospective cohort study
Histological examination
ulcerative colitis
Hepatology
medicine.diagnostic_test
business.industry
Geboes Index
Original Articles
Diseases of the digestive system. Gastroenterology
medicine.disease
Ulcerative colitis
Clinical Practice
030220 oncology & carcinogenesis
Mucosal healing
030211 gastroenterology & hepatology
Original Article
business
Subjects
Details
- ISSN :
- 23979070
- Volume :
- 4
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- JGH open : an open access journal of gastroenterology and hepatology
- Accession number :
- edsair.doi.dedup.....4ee37026a5a8070af0ddaba448c09389