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Hemoglobin bologna (α2β2 61 (E5) Lys → Met) An abnormal human hemoglobin wlth low oxygen affinity

Authors :
A. Giampaolo
L. Tentori
Anna Giuliani
Fulvio Mavilio
A. Massa
Donatella Maffi
Marino Marinucci
M. Zannotti
Source :
Biochimica et Biophysica Acta (BBA) - Protein Structure. 668:209-215
Publication Year :
1981
Publisher :
Elsevier BV, 1981.

Abstract

An abnormal human hemoglobin was found in association with β-thalassemia in a hemolysate from an 11-year-old healthy child living in Bologna (northern) Italy). Structural studies demonstrated a previously unreported amino acid substitution, β 61 (E5) Lys → Met (this is an external residue). The new variant has been named Hb Bologna, and is characterized by a reduced oxygen affinity. Family studies indicated that the variant had been inherited from the father, a 41-year-old male of Southern Italian origin. Also, a brother of the propositus was found to be an abnormal Hb carrier.

Details

ISSN :
00052795
Volume :
668
Database :
OpenAIRE
Journal :
Biochimica et Biophysica Acta (BBA) - Protein Structure
Accession number :
edsair.doi.dedup.....4edc76eac924c889ec33690fcd3916e5