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A complex t(3;8;17) involving breakpoint 8p11 in a case of M5 acute nonlymphocytic leukemia with erythrophagocytosis

Authors :
Anne Hagemeijer
J.C. Le Petit
J. Reynaud
G. Pomier
J. Jaubert
Vasselon C
C.P. Brizard
M.F. Bertheas
Source :
Cancer Genetics and Cytogenetics. 42:67-73
Publication Year :
1989
Publisher :
Elsevier BV, 1989.

Abstract

The t(8;16)(p11;p13) is a recently described new chromosome rearrangement of acute non-lymphocytic leukemia (ANLL). It appears to be specifically associated with acute monoblastic (AML-M5) or unusual myelomonocytic leukemia with prominent erythrophagocytosis in the leukemic cells. A complex t(3;8;17)(q27;p11;q12) is reported in a case of acute monoblastic leukemia with erythrophagocytosis. Sixteen cases of this t(8;16) and two other variant translocations are reviewed. The pathogenetic mechanism of the variant translocations is discussed, suggesting that the der(8) is a consistent recombinant.

Details

ISSN :
01654608
Volume :
42
Database :
OpenAIRE
Journal :
Cancer Genetics and Cytogenetics
Accession number :
edsair.doi.dedup.....4ed30a922e927470478f4d47940592f2