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A complex t(3;8;17) involving breakpoint 8p11 in a case of M5 acute nonlymphocytic leukemia with erythrophagocytosis
- Source :
- Cancer Genetics and Cytogenetics. 42:67-73
- Publication Year :
- 1989
- Publisher :
- Elsevier BV, 1989.
-
Abstract
- The t(8;16)(p11;p13) is a recently described new chromosome rearrangement of acute non-lymphocytic leukemia (ANLL). It appears to be specifically associated with acute monoblastic (AML-M5) or unusual myelomonocytic leukemia with prominent erythrophagocytosis in the leukemic cells. A complex t(3;8;17)(q27;p11;q12) is reported in a case of acute monoblastic leukemia with erythrophagocytosis. Sixteen cases of this t(8;16) and two other variant translocations are reviewed. The pathogenetic mechanism of the variant translocations is discussed, suggesting that the der(8) is a consistent recombinant.
- Subjects :
- congenital, hereditary, and neonatal diseases and abnormalities
Cancer Research
medicine.medical_specialty
Erythrocytes
Myelomonocytic leukemia
Chromosomal translocation
Chromosomal rearrangement
Biology
Translocation, Genetic
Phagocytosis
hemic and lymphatic diseases
Genetics
medicine
Humans
Molecular Biology
Breakpoint
Cytogenetics
Middle Aged
medicine.disease
Erythrophagocytosis
Chromosome Banding
Leukemia
Acute Monoblastic Leukemia
Karyotyping
Leukemia, Monocytic, Acute
Immunology
Female
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 8
Subjects
Details
- ISSN :
- 01654608
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Cancer Genetics and Cytogenetics
- Accession number :
- edsair.doi.dedup.....4ed30a922e927470478f4d47940592f2