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Solriamfetol for Excessive Sleepiness in Narcolepsy and Obstructive Sleep Apnea
- Source :
- The Annals of pharmacotherapy. 54(10)
- Publication Year :
- 2020
-
Abstract
- Objective: The purpose of this article is to review the available clinical trial data that led to the Food and Drug Administration (FDA) approval of solriamfetol as well as its role in clinical practice. Data Sources: A MEDLINE/PubMed search was conducted (January 2000 to February 2020) using the keyword solriamfetol to discover appropriate clinical trials. Study Selection and Data Extraction: Articles were included that were published in the English language and related to the FDA approval of solriamfetol or provided novel information regarding this drug entity. Data Synthesis: The findings of the review show that solriamfetol may be a safe and effective option for the treatment of excessive sleepiness (ES) related to narcolepsy and obstructive sleep apnea (OSA). Relevance to Patient Care and Clinical Practice: Solriamfetol is distinguished from other stimulants in that it has lower binding affinity to dopamine and norepinephrine transporters and does not have the monoamine-releasing effects of amphetamines at usual therapeutic doses. Because of solriamfetol’s unique mechanism of action, there may be a reduction in abuse potential compared with the other currently FDA-approved options. Conclusions: In clinical trials, solriamfetol has shown dose-dependent improvement in wakefulness over placebo and adds another option for clinicians when treating ES in narcolepsy and OSA.
- Subjects :
- medicine.medical_specialty
Sleepiness
Phenylalanine
Disorders of Excessive Somnolence
Food and drug administration
03 medical and health sciences
0302 clinical medicine
Medicine
Humans
Pharmacology (medical)
Intensive care medicine
Narcolepsy
Clinical Trials as Topic
Sleep Apnea, Obstructive
Excessive sleepiness
business.industry
United States Food and Drug Administration
Wakefulness-Promoting Agents
medicine.disease
United States
Obstructive sleep apnea
Clinical trial
Treatment Outcome
030228 respiratory system
Wakefulness
Carbamates
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15426270
- Volume :
- 54
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- The Annals of pharmacotherapy
- Accession number :
- edsair.doi.dedup.....4ec7b31c9e7bbb8d215ed6045f5f551b