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The use of magnetic resonance imaging to noninvasively detect genetic signatures in oligodendroglioma
- Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research. 14(8)
- Publication Year :
- 2008
-
Abstract
- Background: Some patients with low-grade glioma have extraordinarily long survival times; current, early treatment does not prolong their lives. For this reason, therapies that sometimes have neurologic side effects are often deferred intentionally. Methods: In a study of oligodendrogliomas, we used a quantitative method of MR analysis based on the S-transform to investigate whether codeletion of chromosomes 1p and 19q, a marker of good prognosis, could be predicted accurately by measuring image texture. Results: Differences in texture were seen between tumors with codeletion of chromosomes 1p and 19q and those with intact 1p and 19q alleles on contrast-enhanced T1-weighted and T2-weighted MR images. Quantitative MR texture on T2 images predicted codeletion of chromosomes 1p and 19q with high sensitivity and specificity. Conclusions: This new method of MR image interpretation may have the potential to augment the diagnostic assessment of patients with suspected low-grade glioma.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Oligodendroglioma
Image texture
Glioma
medicine
Humans
medicine.diagnostic_test
business.industry
Quantitative mr
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Oncology
Chromosomes, Human, Pair 1
Diagnostic assessment
Female
Good prognosis
Mr images
Chromosome Deletion
business
Chromosomes, Human, Pair 19
Subjects
Details
- ISSN :
- 10780432
- Volume :
- 14
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Accession number :
- edsair.doi.dedup.....4ec77f70ab16fab3f4c2144c3298fe14