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Identification and cornification-related gene expression of canine keratinocyte differentiation-associated protein, Kdap
- Source :
- The Veterinary Journal. 172:141-146
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- The outermost layer of skin, the epidermis, is cornified epithelial tissue composed of keratinocytes. To maintain the structure and function of the epidermis, the regulation of proliferation, differentiation, and cornification of keratinocytes is crucial, and various soluble factors secreted by keratinocytes are involved in these regulations. Previously, work has shown that keratinocytes secreted the protein Kdap (keratinocyte differentiation-associated protein) associated with the formation of cornified cell envelopes, a specialized protective barrier structure on the periphery of terminally differentiating keratinocytes. In the present report, the canine counterpart of human Kdap is identified and an attempt has been made to define its physiological role in canine keratinization. Canine Kdap (cKdap) showed structural features commonly observed in other counterparts and is secreted from transfected cells. The expression profile of cKdap mRNA, which was restrictively expressed in cornified epithelial tissues besides skin has also been determined. These findings indicate that there is a strong association between cKdap expression and cornification, which supports previous observations that Kdap is involved in the synthesis and/or degradation of cornified cell envelopes in humans and mice.
- Subjects :
- Keratinocytes
Pathology
medicine.medical_specialty
Cell
Gene Expression
Biology
Dogs
Species Specificity
Keratin
medicine
Animals
Aspartic Acid Endopeptidases
Amino Acid Sequence
RNA, Messenger
Cloning, Molecular
Related gene
chemistry.chemical_classification
Messenger RNA
Base Sequence
General Veterinary
Cell Differentiation
Transfection
Cell biology
medicine.anatomical_structure
Epidermal Cells
chemistry
Animal Science and Zoology
Epidermis
Keratinocyte differentiation
Keratinocyte
Cell Division
Subjects
Details
- ISSN :
- 10900233
- Volume :
- 172
- Database :
- OpenAIRE
- Journal :
- The Veterinary Journal
- Accession number :
- edsair.doi.dedup.....4eb428866b3c7f0554a00a95b32bb133