Back to Search Start Over

Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human

Authors :
Kevin J. Coe
Mark Feinstein
J. William Higgins
Perry Leung
Brian P. Scott
Judy Skaptason
Yuen Tam
Laurie P. Volak
Jennifer Kinong
Anton Bittner
Heather McAllister
Nathan M. Lim
Michael Hack
Tatiana Koudriakova
Source :
Drug metabolism and disposition: the biological fate of chemicals. 50(8)
Publication Year :
2021

Abstract

[4-(4-Methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-yl)pyrimidine-2-amine] (JNJ-2482272), under investigation as an anti-inflammatory agent, was orally administered to rats once daily at 60 mg/kg for 6 consecutive days. Despite high plasma exposure after single administration (C

Details

ISSN :
1521009X
Volume :
50
Issue :
8
Database :
OpenAIRE
Journal :
Drug metabolism and disposition: the biological fate of chemicals
Accession number :
edsair.doi.dedup.....4e7ffacc86d3af23c0c9e8fefda12a2a