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Suppressive effects of garlic extract on Helicobacter pylori-induced gastritis in Mongolian gerbils
- Source :
- Cancer letters. 187(1-2)
- Publication Year :
- 2002
-
Abstract
- Helicobacter pylori infection is intimately involved in stomach cancer development and recent epidemiological studies have indicated that the consumption of allium vegetables reduces the risk of gastric neoplasia. Therefore, in the present study, we investigated the effect of a garlic extract on H. pylori-induced gastritis in Mongolian gerbils. Garlic extract was fed to animals at doses of 1, 2 and 4% in the diet from 4 h after H. pylori inoculation until the end of the experiment, at week 6. With the administration of garlic extract, H. pylori-induced gastritis in animals was decreased in a dose-dependent manner, and significantly so at 4%. The numbers of hemorrhagic spots in the glandular stomach and the microscopic score for gastritis were significantly reduced from 19.2+/-15.6 and 5.9+/-0.8 in control gerbils to 8.1+/-11.2 and 4.2+/-1.5, respectively, by 4% garlic extract treatment. The stomach wet weight (1.04+/-0.22 g) of control gerbils was also reduced by 4% garlic extract (0.86+/-0.18 g). However, the number of viable H. pylori was not changed by the garlic extract treatment. The above observations indicated that garlic extract might be useful as an agent for prevention of H. pylori-induced gastritis, leading to reduction in the risk of gastric cancer.
- Subjects :
- Male
Cancer Research
law.invention
Helicobacter Infections
law
medicine
Animals
Helicobacter
Stomach cancer
Garlic
Traditional medicine
biology
Dose-Response Relationship, Drug
Helicobacter pylori
business.industry
Plant Extracts
Stomach
food and beverages
Allium sativum
biology.organism_classification
medicine.disease
Anti-Bacterial Agents
Diet
Disease Models, Animal
medicine.anatomical_structure
Oncology
Gastritis
Allium
medicine.symptom
Phytotherapy
business
Gerbillinae
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 187
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Cancer letters
- Accession number :
- edsair.doi.dedup.....4e642aca08ce3d13c42d756f956a7f01