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Bacterial Profile and Antibiotic Resistance in Patients with Diabetic Foot Ulcer in Guangzhou, Southern China: Focus on the Differences among Different Wagner's Grades, IDSA/IWGDF Grades, and Ulcer Types
- Source :
- International Journal of Endocrinology, International Journal of Endocrinology, Vol 2017 (2017)
- Publication Year :
- 2017
-
Abstract
- Objective. To understand the bacterial profile and antibiotic resistance patterns in diabetic foot infection (DFI) in different Wagner’s grades, IDSA/IWGDF grades, and different ulcer types in Guangzhou, in order to provide more detailed suggestion to the clinician about the empirical antibiotic choice. Methods. 207 bacteria were collected from 117 DFIs in Sun Yat-sen Memorial Hospital from Jan.1, 2010, to Dec.31, 2015. The clinical data and microbial information were analyzed. Results. The proportion of Gram-negative bacteria (GNB) was higher than Gram-positive bacteria (GPB) (54.1% versus 45.9%), in which Enterobacteriaceae (73.2%) and Staphylococcus (65.2%) were predominant, respectively. With an increasing of Wagner’s grades and IDSA/IWGDF grades, the proportion of GNB bacterial infection, especially Pseudomonas, was increased. Neuro-ischemic ulcer (N-IFU) was more susceptible to GNB infection. Furthermore, with the aggravation of the wound and infection, the antibiotic resistance rates were obviously increased. GPB isolated in ischemic foot ulcer (IFU) showed more resistance than the N-IFU, while GNB isolates were on the opposite. Conclusions. Different bacterial profiles and antibiotic sensitivity were found in different DFU grades and types. Clinician should try to stay updated in antibiotic resistance pattern of common pathogens in their area. This paper provided them the detailed information in this region.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Article Subject
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Antibiotic sensitivity
030106 microbiology
Antibiotics
030209 endocrinology & metabolism
medicine.disease_cause
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Microbiology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Antibiotic resistance
Internal medicine
Medicine
In patient
lcsh:RC648-665
Endocrine and Autonomic Systems
business.industry
medicine.disease
Diabetic foot
Diabetic foot ulcer
Southern china
business
Staphylococcus
Research Article
Subjects
Details
- ISSN :
- 16878337
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- International journal of endocrinology
- Accession number :
- edsair.doi.dedup.....4e52ae54f9d0a4c399bb3b3836ac1b8b