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Active Crohn's disease is associated with low vitamin D levels
- Source :
- Jørgensen, S P, Hvas, C L, Agnholt, J, Christensen, L A, Heickendorff, L & Dahlerup, J F 2013, ' Active Crohn's disease is associated with low vitamin D levels ', Journal of Crohn's & colitis, vol. 7, no. 10, pp. e407–e413 . https://doi.org/10.1016/j.crohns.2013.01.012
- Publication Year :
- 2012
-
Abstract
- BACKGROUND AND AIMS: Crohn's disease prevalence increases with increasing latitude. Because most vitamin D comes from sunlight exposure and murine models of intestinal inflammation have demonstrated beneficial effects of 1,25-(OH)(2) vitamin D treatment, we hypothesised that Crohn's disease activity is associated with low vitamin D levels.METHODS: In a cross-sectional study of 182 CD patients and 62 healthy controls, we measured serum 25-OH vitamin D. Stratified analysis was used to compare 25-OH vitamin D levels with Crohn's disease activity index, C-reactive protein, smoking status, intake of oral vitamin D supplements and seasonal variation in CD patients and healthy controls.RESULTS: Serum 25-OH vitamin D was inversely associated with disease activity: Median 25-OH vitamin D levels of Crohn's disease in remission, mildly, and moderately active diseases evaluated by Crohn's disease activity index were 64, 49, and 21nmol/l (pCONCLUSIONS: Active Crohn's disease was associated with low serum 25-OH vitamin D. Patients who smoked had lower 25-OH vitamin D levels than patients who did not smoke, independently of disease activity. BACKGROUND AND AIMS: Crohn's disease prevalence increases with increasing latitude. Because most vitamin D comes from sunlight exposure and murine models of intestinal inflammation have demonstrated beneficial effects of 1,25-(OH)(2) vitamin D treatment, we hypothesised that Crohn's disease activity is associated with low vitamin D levels. METHODS: In a cross-sectional study of 182 CD patients and 62 healthy controls, we measured serum 25-OH vitamin D. Stratified analysis was used to compare 25-OH vitamin D levels with Crohn's disease activity index, C-reactive protein, smoking status, intake of oral vitamin D supplements and seasonal variation in CD patients and healthy controls. RESULTS: Serum 25-OH vitamin D was inversely associated with disease activity: Median 25-OH vitamin D levels of Crohn's disease in remission, mildly, and moderately active diseases evaluated by Crohn's disease activity index were 64, 49, and 21nmol/l (p
- Subjects :
- Vitamin
Adult
Male
medicine.medical_specialty
Adolescent
Disease
Calcitriol receptor
Severity of Illness Index
chemistry.chemical_compound
Young Adult
Crohn Disease
Internal medicine
medicine
Vitamin D and neurology
Humans
Interferon gamma
Vitamin D
Aged
Crohn's disease
biology
business.industry
C-reactive protein
Smoking
Gastroenterology
General Medicine
Vitamins
Middle Aged
medicine.disease
Crohn's Disease Activity Index
Endocrinology
C-Reactive Protein
Cross-Sectional Studies
chemistry
Case-Control Studies
Dietary Supplements
biology.protein
Female
Seasons
business
medicine.drug
Subjects
Details
- ISSN :
- 18764479
- Volume :
- 7
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Crohn'scolitis
- Accession number :
- edsair.doi.dedup.....4e48081cda1395a3745c2d54687d679d
- Full Text :
- https://doi.org/10.1016/j.crohns.2013.01.012