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Active Crohn's disease is associated with low vitamin D levels

Authors :
Søren Peter Jørgensen
Lene Heickendorff
Jørgen Agnholt
Jens Frederik Dahlerup
Christian Lodberg Hvas
Lisbet Ambrosius Christensen
Source :
Jørgensen, S P, Hvas, C L, Agnholt, J, Christensen, L A, Heickendorff, L & Dahlerup, J F 2013, ' Active Crohn's disease is associated with low vitamin D levels ', Journal of Crohn's & colitis, vol. 7, no. 10, pp. e407–e413 . https://doi.org/10.1016/j.crohns.2013.01.012
Publication Year :
2012

Abstract

BACKGROUND AND AIMS: Crohn's disease prevalence increases with increasing latitude. Because most vitamin D comes from sunlight exposure and murine models of intestinal inflammation have demonstrated beneficial effects of 1,25-(OH)(2) vitamin D treatment, we hypothesised that Crohn's disease activity is associated with low vitamin D levels.METHODS: In a cross-sectional study of 182 CD patients and 62 healthy controls, we measured serum 25-OH vitamin D. Stratified analysis was used to compare 25-OH vitamin D levels with Crohn's disease activity index, C-reactive protein, smoking status, intake of oral vitamin D supplements and seasonal variation in CD patients and healthy controls.RESULTS: Serum 25-OH vitamin D was inversely associated with disease activity: Median 25-OH vitamin D levels of Crohn's disease in remission, mildly, and moderately active diseases evaluated by Crohn's disease activity index were 64, 49, and 21nmol/l (pCONCLUSIONS: Active Crohn's disease was associated with low serum 25-OH vitamin D. Patients who smoked had lower 25-OH vitamin D levels than patients who did not smoke, independently of disease activity. BACKGROUND AND AIMS: Crohn's disease prevalence increases with increasing latitude. Because most vitamin D comes from sunlight exposure and murine models of intestinal inflammation have demonstrated beneficial effects of 1,25-(OH)(2) vitamin D treatment, we hypothesised that Crohn's disease activity is associated with low vitamin D levels. METHODS: In a cross-sectional study of 182 CD patients and 62 healthy controls, we measured serum 25-OH vitamin D. Stratified analysis was used to compare 25-OH vitamin D levels with Crohn's disease activity index, C-reactive protein, smoking status, intake of oral vitamin D supplements and seasonal variation in CD patients and healthy controls. RESULTS: Serum 25-OH vitamin D was inversely associated with disease activity: Median 25-OH vitamin D levels of Crohn's disease in remission, mildly, and moderately active diseases evaluated by Crohn's disease activity index were 64, 49, and 21nmol/l (p

Details

ISSN :
18764479
Volume :
7
Issue :
10
Database :
OpenAIRE
Journal :
Journal of Crohn'scolitis
Accession number :
edsair.doi.dedup.....4e48081cda1395a3745c2d54687d679d
Full Text :
https://doi.org/10.1016/j.crohns.2013.01.012