Genetic diversity and antifungal susceptibility of Candida albicans isolated from Iranian patients

Authors :: Seyedmojtaba Seyedmousavi
Atefe Hadian
Vida Mortezaee
Somayeh Sharifynia
Abdolreza Mohamadnia
Sasan Rezaie
Source :: Medical Mycology. 57:127-131
Publication Year :: 2018
Publisher :: Oxford University Press (OUP), 2018.
Abstract: A total of 105 independent Candida albicans strains isolated from patients in Iran were investigated. According to CLSI documents M27-A3 and M27-S4, the 24 h geometric mean MICs of caspofungin, itraconazole, and fluconazole were 0.27, 3.19, and 11.91 μg/ml, respectively. Microsatellites analysis of CEF3, CAIII, LOC4 Loci identified 93 different allelic genotypes clustered apart into six different clades. Antifungal susceptibility was not linked with the source of isolation and the corresponding genotype of C. albicans strains.

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