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A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes
- Source :
- PLoS ONE, Vol 13, Iss 12, p e0208654 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Public Library of Science, 2018.
-
Abstract
- To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p < 1.0 x 10^) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 x 10^. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 x 10^). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.<br />論文
- Subjects :
- Male
0301 basic medicine
Physiology
Genome-wide association study
Type 2 diabetes
Gastroenterology
Diabetic nephropathy
MELLITUS
Endocrinology
Mathematical and Statistical Techniques
Japan
Chronic Kidney Disease
Medicine and Health Sciences
Diabetic Nephropathies
COMPLICATIONS
Multidisciplinary
Statistics
Genomics
Metaanalysis
Middle Aged
Type 2 Diabetes
3. Good health
Physiological Parameters
Nephrology
OBESITY
Physical Sciences
Medicine
Female
Research Article
medicine.medical_specialty
Endocrine Disorders
Science
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Single-nucleotide polymorphism
Research and Analysis Methods
Polymorphism, Single Nucleotide
Nephropathy
Molecular Genetics
03 medical and health sciences
Internal medicine
Diabetes mellitus
Diabetes Mellitus
Genome-Wide Association Studies
Genetics
medicine
Humans
Genetic Predisposition to Disease
Statistical Methods
GENOME-WIDE ASSOCIATION
Molecular Biology
Aged
Genetic association
business.industry
Body Weight
Case-control study
Biology and Life Sciences
Computational Biology
Human Genetics
Genome Analysis
medicine.disease
GENE
POLYMORPHISM
RENAL-DISEASE
030104 developmental biology
Diabetes Mellitus, Type 2
Genetic Loci
Metabolic Disorders
Case-Control Studies
3111 Biomedicine
business
Mathematics
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....4e40677824ebd6ff98dac27d45663f63