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Gold(III)-catalyzed synthesis of 2,5-disubstituted furans from substituted 5-methoxyhex-3-yn-2-ols—Mechanistic outlook
- Source :
- Synthetic Communications. 51:3090-3098
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Gold(III)-catalyzed activation of alkynes has been applied for the synthesis of 2,5-disubstituted furans from substituted 5-methoxy-hex-3-yn-2-ols. Mechanistically, the reaction proceeds via an allenyl carbocation intermediate followed by 5-endo-dig cyclization. The high-yielding, open-air, room temperature reaction conditions applied to synthesize a series of alkyl, aryl, and hetero aryl-substituted furans provide uniqueness to the strategy.
Details
- ISSN :
- 15322432 and 00397911
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Synthetic Communications
- Accession number :
- edsair.doi.dedup.....4e2631992bec40db8260612bc6681393