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ERCC1 SNPs as Potential Predictive Biomarkers in Non-Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy
- Source :
- Cancer investigation. 33(4)
- Publication Year :
- 2015
-
Abstract
- Polymorphisms in ERCC1, XPD, and XRCC1 were examined for (a) association with the clinical outcome of 107 non-small cell lung cancer patients receiving front-line platinum-based chemotherapy, and (b) correlation with the ERCC1 mRNA levels of 176 chemo-naive primary tumors. The ERCC1-C8092 allele and the number of ERCC1 polymorphic variants (C8092A and Asn118Asn) were associated with progression-free survival. In non-squamous histology, tumoral ERCC1 mRNA levels were lower in patients homozygous for ERCC1-C8092 as compared with the patients carrying the A allele (p = .024). These findings merit investigation in larger cohorts of patients treated with uniform regimens.
- Subjects :
- Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
XRCC1
Internal medicine
Carcinoma, Non-Small-Cell Lung
Antineoplastic Combined Chemotherapy Protocols
medicine
Biomarkers, Tumor
Humans
RNA, Messenger
Allele
Lung cancer
Aged
Platinum
Chemotherapy
Histology
General Medicine
Middle Aged
medicine.disease
Endonucleases
DNA-Binding Proteins
Cancer research
Female
Non small cell
ERCC1
Subjects
Details
- ISSN :
- 15324192
- Volume :
- 33
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Cancer investigation
- Accession number :
- edsair.doi.dedup.....4e08438d811a72426f71e7d4c0d09ff2