Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP

Authors :: Christopher J. Ong
Lu Yang
Alice Mui
R.W.M. van Soest
Gerald Krystal
David E. Williams
Raymond J. Andersen
Research of the Zoological Museum of Amsterdam (ZMA)
Systematische en Geografische Dierkunde (inactive) (IBED, FNWI)
Source :: Organic Letters, 7(6), 1073-1076. American Chemical Society
Publication Year :: 2005
Abstract: [reaction: see text] A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analogues have been synthesized from sclareolide (4).

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