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The prognostic impact of macroscopic serosal change on resectable advanced gastric cancer
- Source :
- BMC Cancer, BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Background Advanced gastric cancer sometimes causes macroscopic serosal change (MSC) due to direct invasion or inflammation. However, the prognostic significance of MSC remains unclear. Methods A total of 1410 patients who had been diagnosed with deeper-than-pathological-T2 gastric cancer and undergone R0 gastrectomy with lymph node dissection at the National Cancer Center Hospital during January 2000 and December 2012 were restrospectively reviewed. Results MSC was not found in 108 of the 506 patients with pathological T4a (21.3%), whereas it was detected in 250 of the 904 patients with pathological T2-T3 (27.7%). The sensitivity, specificity and accuracy for diagnosing pathological serosa exposed (SE) by MSC were 78.7, 72.3 and 74.6%, respectively. The MSC-positive cases had a worse 5-year overall survival (OS) than the MSC-negative cases in pT3 (72.9% vs. 84.3%, p = 0.001), pT4a (56.2% vs. 73.4%, p = 0.001), pStageIIB (76.0% vs. 88.4%, p = 0.005), pStageIIIA (63.4% vs. 75.6%, p = 0.019), pStageIIIB (53.6% vs. 69.2%, p = 0.029) and pStage IIIC (27.6% vs. 50.0%, p = 0.062). A multivariate analysis showed that MSC was a significant independent predictor for the OS (hazard ratio [HR]: 1.587, 95%CI 1.209–2.083, p = 0.001) along with the tumor depth (HR: 7.742, 95%CI: 2.935–20.421, p p p Conclusions In this study, the MSC was one of the independent prognostic factors in patients with resectable locally advanced gastric cancer.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Gastroenterology
Sensitivity and Specificity
Serous Membrane
Surgical oncology
Gastrectomy
Stomach Neoplasms
Internal medicine
Genetics
medicine
Confidence Intervals
Humans
Neoplasm Invasiveness
Stage (cooking)
Lymph node
Pathological
RC254-282
Aged
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
Prognostic factor
Analysis of Variance
business.industry
Hazard ratio
Cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Middle Aged
medicine.disease
Prognosis
Macroscopic serosal change
Dissection
medicine.anatomical_structure
Oncology
Lymph Node Excision
Female
Lymph Nodes
Neoplasm Recurrence, Local
business
Gastric cancer
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....4dfce104e1a4ebca06b8a76893066869