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Effects of antenatal dexamethasone and hyperglycemia on cardiovascular adaptation to asphyxia in preterm fetal sheep
- Source :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 319:R653-R665
- Publication Year :
- 2020
- Publisher :
- American Physiological Society, 2020.
-
Abstract
- Antenatal glucocorticoids improve outcomes among premature infants but are associated with hyperglycemia, which can exacerbate hypoxic-ischemic injury. It is still unclear how antenatal glucocorticoids or hyperglycemia modulate fetal cardiovascular adaptations to severe asphyxia. In this study, preterm fetal sheep received either saline or 12 mg im maternal dexamethasone, followed 4 h later by complete umbilical cord occlusion (UCO) for 25 min. An additional cohort of fetuses received titrated glucose infusions followed 4 h later by UCO to control for the possibility that hyperglycemia contributed to the cardiovascular effects of dexamethasone. Fetuses were studied for 7 days after UCO. Maternal dexamethasone was associated with fetal hyperglycemia ( P < 0.001), increased arterial pressure ( P < 0.001), and reduced femoral ( P < 0.005) and carotid ( P < 0.05) vascular conductance before UCO. UCO was associated with bradycardia, femoral vasoconstriction, and transient hypertension. For the first 5 min of UCO, fetal blood pressure in the dexamethasone-asphyxia group was greater than saline-asphyxia ( P < 0.001). However, the relative increase in arterial pressure was not different from saline-asphyxia. Fetal heart rate and femoral vascular conductance fell to similar nadirs in both saline and dexamethasone-asphyxia groups. Dexamethasone did not affect the progressive decline in femoral vascular tone or arterial pressure during continuing UCO. By contrast, there were no effects of glucose infusions on the response to UCO. In summary, maternal dexamethasone but not fetal hyperglycemia increased fetal arterial pressure before and for the first 5 min of prolonged UCO but did not augment the cardiovascular adaptations to acute asphyxia.
- Subjects :
- Blood Glucose
Bradycardia
medicine.medical_specialty
Time Factors
Physiology
medicine.medical_treatment
Gestational Age
030204 cardiovascular system & hematology
Dexamethasone
03 medical and health sciences
Fetal Heart
0302 clinical medicine
Heart Rate
Physiology (medical)
Internal medicine
medicine
Animals
Arterial Pressure
Glucocorticoids
Saline
Sheep, Domestic
Asphyxia
Asphyxia Neonatorum
Fetus
business.industry
Hemodynamics
medicine.disease
Disease Models, Animal
Blood pressure
Animals, Newborn
Premature birth
Hyperglycemia
Cardiology
Premature Birth
medicine.symptom
business
Biomarkers
030217 neurology & neurosurgery
Vasoconstriction
medicine.drug
Subjects
Details
- ISSN :
- 15221490 and 03636119
- Volume :
- 319
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Accession number :
- edsair.doi.dedup.....4df241edc5f4eb031256e62caca9c23f
- Full Text :
- https://doi.org/10.1152/ajpregu.00216.2020