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Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [11C]PiB amyloid imaging
- Source :
- EJNMMI Physics, EJNMMI Physics, Vol 8, Iss 1, Pp 1-16 (2021)
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Purpose Partial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate the effect of misspecification of scanner point-spread function (PSF) on GTM results in amyloid imaging, including the effect on amyloid status classification (positive or negative). Methods Twenty-nine subjects with Pittsburgh Compound B ([11C]PiB) PET and structural T1 MR imaging were analyzed. FreeSurfer 5.3 (FS) was used to parcellate MR images into regions-of-interest (ROIs) that were used to extract radioactivity concentration values from the PET images. GTM PVC was performed using our “standard” PSF parameterization [3D Gaussian, full-width at half-maximum (w) of approximately 5 mm]. Additional GTM PVC was performed with “incorrect” parameterizations, taken around the correct value. The result is a set of regional activity values for each of the GTM applications. For each case, activity values from various ROIs were combined and normalized to produce standardized uptake value ratios (SUVRs) for nine standard [11C]PiB quantitation ROIs and a global region. GTM operating-point characteristics were determined from the slope of apparent SUVR versus w curves. Results Errors in specification of w on the order of 1 mm (3D) mainly produce only modest errors of up to a few percent. An exception was the anterior ventral striatum in which fractional errors of up to 0.29 per millimeter (3D) of error in w were observed. Conclusion While this study does not address all the issues regarding the quantitative strengths and weakness of GTM PVC, we find that with reasonable caution, the unavoidable inaccuracies associated with PSF specification do not preclude its use in amyloid quantitation.
- Subjects :
- Point spread function
Positron emission tomography
Scanner
Gaussian
R895-920
Biomedical Engineering
Standardized uptake value
Partial volume effect correction
030218 nuclear medicine & medical imaging
Medical physics. Medical radiology. Nuclear medicine
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Evaluation and performance
medicine
Radiology, Nuclear Medicine and imaging
Instrumentation
Image resolution
Original Research
Mathematics
Radiation
medicine.diagnostic_test
Brain
Transfer matrix
Quantification and estimation
Specification
symbols
Nuclear imaging
030217 neurology & neurosurgery
Biomedical engineering
Subjects
Details
- ISSN :
- 21977364
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- EJNMMI Physics
- Accession number :
- edsair.doi.dedup.....4defdd7e596845bd93f5caaad7100573