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Hachijodines A-G: seven new cytotoxic 3-alkylpyridne alkaloids from two marine sponges of the genera Xetospongia and Amphimedon
- Source :
- Journal of natural products, 63(5), 682-684. American Chemical Society
- Publication Year :
- 2000
- Publisher :
- American Chemical Society, 2000.
-
Abstract
- Seven cytotoxic 3-alkylpyridine alkaloids, hachijodines A-G, have been isolated from two marine sponges of the genera Xestospongia and Amphimedon. Their structures were determined on the basis of spectral data. These alkaloids are moderately cytotoxic against P388 murine leukemia cells with IC(50) values of 1.0-2.3 microg/mL.
- Subjects :
- Marine sponges
Magnetic Resonance Spectroscopy
Stereochemistry
Pharmaceutical Science
Antineoplastic Agents
Spectrometry, Mass, Fast Atom Bombardment
Biology
Analytical Chemistry
Mice
Alkaloids
Drug Discovery
Botany
Tumor Cells, Cultured
Animals
Cytotoxic T cell
heterocyclic compounds
Spectral data
Pharmacology
Leukemia P388
Organic Chemistry
biology.organism_classification
Porifera
Complementary and alternative medicine
Molecular Medicine
Spectrophotometry, Ultraviolet
P388 leukemia
Xestospongia
Drug Screening Assays, Antitumor
Amphimedon
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 63
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of natural products
- Accession number :
- edsair.doi.dedup.....4debc5e703d56733e29784dc78919dc0
- Full Text :
- https://doi.org/10.1021/np9905766